In 2003 Shimon Sakaguchi linked prior findings by showing that the Foxp3 gene controls the development of regulatory T cells, and that regulatory T cells act to suppress other T cells that would otherwise overreact.
January 01, 2003
high
temporal
Functional linkage between a specific gene and the development and immunosuppressive role of regulatory T cells.
A 2001 discovery by Mary E. Brunkow and Fred Ramsdell identified a mutation in the Foxp3 gene that is associated with a rare human autoimmune disease.
January 01, 2001
high
temporal
Identification of a genetic mutation linked to immune dysregulation and a rare autoimmune disorder.