Entity: Perelman School of Medicine at the University of Pennsylvania
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Perelman School of Medicine at the University of Pennsylvania

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A 2025 University of Pennsylvania study found that higher exposure to fine particulate matter (PM2.5) in the year before death was associated with 19% higher odds of having more severe Alzheimer's-type brain changes.
January 01, 2025 high temporal
Association derived from postmortem brain examinations linking recent PM2.5 exposure to Alzheimer's-type pathology.
A 2025 University of Pennsylvania study estimated that approximately 63% of the association between PM2.5 exposure and dementia severity was explained (mediated) by Alzheimer's-related brain pathology.
January 01, 2025 high temporal
Quantifies the portion of the air pollution–dementia severity link attributable to Alzheimer's-type brain changes.
A 2025 University of Pennsylvania study examined postmortem brains from 602 people in the Penn Medicine Brain Bank and estimated individual PM2.5 exposure during the year before death using residential address.
January 01, 2025 high temporal
Describes the study's sample size and the method used to estimate recent air pollution exposure.
A 2025 University of Pennsylvania study reported that among 287 individuals who had dementia assessments before death, higher PM2.5 exposure was associated with greater cognitive and functional decline, including memory loss, impaired judgment, and difficulty with personal care and speech.
January 01, 2025 high temporal
Subgroup analysis linking higher recent PM2.5 exposure to worsened cognitive and daily-function outcomes in individuals with pre-death dementia assessments.