In 2003 Shimon Sakaguchi linked prior findings by showing that the Foxp3 gene controls the development of regulatory T cells, and that regulatory T cells act to suppress other T cells that would otherwise overreact.
January 01, 2003
high
temporal
Functional linkage between a specific gene and the development and immunosuppressive role of regulatory T cells.
A 1995 discovery by Shimon Sakaguchi identified a previously unknown T cell subtype called regulatory T cells (T-regs).
January 01, 1995
high
temporal
Discovery of a distinct T cell subtype with regulatory function.