Entity: U.S. Centers for Disease Control and Prevention (CDC)
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U.S. Centers for Disease Control and Prevention (CDC)

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The United States had 105,007 drug-involved overdose deaths in 2023, as reported by the National Center for Health Statistics via CDC WONDER.
December 31, 2023 high temporal
Annual count of drug-involved overdose deaths from U.S. vital statistics (CDC WONDER).
Opioid-involved overdose deaths in the United States were 81,806 in 2022 and decreased to 79,358 in 2023, according to NCHS data available via CDC WONDER.
December 31, 2023 high temporal
Yearly counts of overdose deaths involving any opioid (prescription opioids, heroin, synthetic opioids other than methadone, etc.).
Overdose deaths in the United States involving synthetic opioids other than methadone (primarily illicitly manufactured fentanyl) numbered 73,838 in 2022 and 72,776 in 2023, per NCHS data from CDC WONDER.
December 31, 2023 high temporal
Counts reflect overdose deaths where synthetic opioids other than methadone were involved; illicitly manufactured fentanyl (IMF) is the primary driver of this category.
U.S. drug overdose deaths involving stimulants (cocaine or psychostimulants with abuse potential) rose from 12,122 in 2015 to 59,725 in 2023, and nearly 70% of stimulant-involved overdose deaths in 2023 also involved illicitly manufactured fentanyl (IMF), according to NCHS data via CDC WONDER.
December 31, 2023 high temporal
Long-term increase in stimulant-involved overdose deaths and high co-involvement with illicitly manufactured fentanyl in 2023.