Huntington's disease is a rare, inherited neurodegenerative disorder caused by a mutation in the HTT gene that leads to production of an abnormal huntingtin protein which progressively damages neurons in the brain.
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General definition and genetic cause of Huntington's disease.
Huntington's disease typically has onset between about 30 and 50 years of age.
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Typical age range when neurological symptoms of Huntington's disease begin.
Huntington's disease commonly produces progressive movement, cognitive, and psychiatric symptoms and typically leads to disability and death within approximately 20 years after the start of neurological symptoms.
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Typical clinical course and prognosis following symptomatic onset.
Neurofilament light protein (NfL) measured in cerebrospinal fluid increases as neurons are damaged and is used as a biomarker of neuronal injury in Huntington's disease.
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Use of NfL as a biomarker to indicate neuronal damage in neurodegenerative conditions.