September 29, 2025
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Study Links GLP‑1 Drugs to Lower Cancer Risk in Women

A large observational study published in JAMA Oncology by researchers at Indiana University and the University of Florida analyzed electronic health records from 2014–2024 for 86,632 adults eligible for anti‑obesity medications and found GLP‑1 receptor agonist use was associated with a significantly lower overall cancer risk—notably endometrial, ovarian and meningioma cancers—while also noting an association with higher kidney‑cancer incidence; authors call for longer‑term follow‑up to clarify mechanisms and clinical implications.

Health Science

🔍 Key Facts

  • Sample size: 86,632 adults eligible for anti‑obesity medications, 68.2% female, study period 2014–2024
  • Findings: GLP‑1 use associated with significantly lower overall cancer risk and reduced incidence of endometrial, ovarian and meningioma cancers
  • Safety signal: study observed an association between GLP‑1 use and increased kidney cancer risk; researchers recommend additional study and clinician monitoring