Nobel Prize in Medicine Awarded for Peripheral Immune Tolerance
The Nobel Prize in Medicine was awarded to Shimon Sakaguchi (University of Osaka), Mary E. Brunkow (Institute for Systems Biology, Seattle) and Fred Ramsdell (Sonoma Biotherapeutics, San Francisco) for their discovery of mechanisms of peripheral immune tolerance. The $1.17 million prize will be shared; Karolinska Institute’s Rickard Sandberg called the work fundamental, and the field now has “more than 200 clinical tests ongoing.”
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📌 Key Facts
- The Nobel Prize in Medicine was awarded for the discovery of peripheral immune tolerance—described in coverage as the immune system’s 'security guards'.
- Laureates named in the report are Shimon Sakaguchi (University of Osaka), Mary E. Brunkow (Institute for Systems Biology, Seattle), and Fred Ramsdell (Sonoma Biotherapeutics, San Francisco).
- The monetary prize to be shared among the laureates is $1.17 million.
- The Science article includes a direct quote from Rickard Sandberg of the Karolinska Institute characterizing the discovery's importance.
- The report notes that there are 'more than 200 clinical tests ongoing' in the peripheral tolerance field, indicating substantial clinical translation activity.
- This coverage was published by Science on 2025-10-06.
📰 Sources (2)
Medicine Nobel for researchers who discovered immune system's security guards
New information:
- Specifies institutional affiliations for the laureates: Mary E. Brunkow (Institute for Systems Biology, Seattle) and Fred Ramsdell (Sonoma Biotherapeutics, San Francisco); Shimon Sakaguchi is identified with University of Osaka.
- Includes a direct quote from Rickard Sandberg (Karolinska Institute) characterizing the discovery's importance.
- Notes the monetary prize amount to be shared: $1.17 million.
- Reports a concrete activity measure: 'more than 200 clinical tests ongoing' in the peripheral tolerance field (quoted).