A 2024 study found that depression-related genetic variants identified in women show stronger overlap with genetic signals linked to metabolic traits compared with those identified in men, suggesting a genetic connection between depression in women and metabolic symptoms such as weight change or altered energy.
January 01, 2024
high
temporal
Reported genetic overlap between depression-associated variants and metabolic trait loci in female cases.
Gut bacteria in the small intestine can metabolize dietary fructose before that fructose reaches the liver.
medium
physiological
Microbial metabolism of sugars in the small intestine can reduce the amount of sugar delivered to the liver.
Dietary fibers that feed gut microbes (prebiotics) can decrease the amount of dietary fructose reaching the liver and thereby have the potential to reduce hepatic fat accumulation and oxidative stress associated with early fatty liver disease.
medium
clinical potential
Prebiotic fibers support microbial consumption of fructose in the gut, which may lower liver exposure to fructose and its downstream metabolic effects.